Research

Host-responses to infection

Characterizing host response to infection and host-directed interventions

Studying lipid metabolism deregulation in TB

Summary We also studied host responses to M. tuberculosis infection using computational approaches: characterizing the transcriptional response in infected macrophages under various small molecule perturbations using RNA-Seq analysis; understanding the dysregulation of lipid metabolism in M. tuberculosis-infected macrophages using dynamic Bayesian model and statistical analyses of heterogeneous single-cell populations. Collaborators Rutgers University Marila Gennaro Sanjay Tyagi Eduardo Sontag (now in North Eastern) Tulane University Deepak Kaushal Knowledge Synthesis Hugh Salamon

Stochastic nature of adipogenic and inflammatory responses in tuberculous macrophages

The Psp system of Mycobacterium tuberculosis integrates envelope stress-sensing and envelope-preserving functions

The bacterial envelope integrates essential stress-sensing and adaptive functions; thus, envelope-preserving functions are important for survival. In Gram-negative bacteria, envelope integrity during stress is maintained by the multi-gene Psp …

Mathematical modeling of pathways involved in cell cycle regulation and Differentiation

Cutting edge: Vitamin D regulates lipid metabolism in Mycobacterium tuberculosis infection

Dynamical Systems & Modeling

Mathematical modeling of pathways involved in cell cycle regulation and differentiation

Modeling the START transition in the budding yeast cell cycle

Modeling the START transition in the budding yeast cell cycle

Modeling the START transition and size control in budding yeast